English
Noun
second puberty (uncountable)
- (slang, medicine) The physical, hormonal, and emotional changes that occur in adulthood.
- (transgender) The physical, hormonal, and emotional changes that occur during a hormone replacement therapy.
2024 October 25, Helene Frances Hedian, M.D., “Gender-Affirming Hormone Therapy (GAHT)”, in John Hopkins Medicine[1], archived from the original on 22 August 2025:During gender-affirming hormone therapy, you will go through what is called a “second puberty.” This means that the same emotional struggles that your first puberty may have brought — mood swings, anxiety and depression — are possibilities as an adult during your second puberty.